Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach

PARP-1 inhibition has been studied over the last decades for the treatment of various diseases. Despite the fact that several molecules act as PARP-1 inhibitors, a reduced number of compounds are used in clinical practice. To identify new compounds with a discriminatory PARP-1 inhibitory function, e...

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Detalles Bibliográficos
Autores principales: Baptista, Salete J., Silva, Maria M. C., Moroni, Elisabetta, Meli, Massimiliano, Colombo, Giorgio, Dinis, Teresa C. P., Salvador, Jorge A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266331/
https://www.ncbi.nlm.nih.gov/pubmed/28122037
http://dx.doi.org/10.1371/journal.pone.0170846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266331/
https://www.ncbi.nlm.nih.gov/pubmed/28122037
http://dx.doi.org/10.1371/journal.pone.0170846

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