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Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit

PURPOSE: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the risk factors. DESIGN: Retrospective, comparative, interventional case series. METHODS: Data of all patients with BCC between 2008 and 2...

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Autores principales: Furdova, Alena, Lukacko, Pavol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266411/
https://www.ncbi.nlm.nih.gov/pubmed/27906855
http://dx.doi.org/10.1097/SCS.0000000000003242
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author Furdova, Alena
Lukacko, Pavol
author_facet Furdova, Alena
Lukacko, Pavol
author_sort Furdova, Alena
collection PubMed
description PURPOSE: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the risk factors. DESIGN: Retrospective, comparative, interventional case series. METHODS: Data of all patients with BCC between 2008 and 2014 were reviewed for patient demographics, previous treatment options, tumor localization, and histopathologic subtype. RESULTS: In group of 256 patients, orbital exenteration underwent 7 patients (2.7%). For 2 patients (5.1%), orbital exenteration was the first procedure performed. In the exenterated group, the most common tumor site was the medial cantus and lower eyelid, whereas in the overall group, it was the lower eyelid (P = 0.011). The proportion of patients initially treated with histopathologic result of infiltration of 1 margin was significantly higher in patients undergoing exenteration (P = 0.282). During the 7-year period observership, the authors have seen 13 recurrences (5.08%). In patients with recurrent BCC after surgery, the authors applied adjuvant high dose rate (192)Ir brachytherapy. Neoadjuvant therapy with Vismodegib was effective in patient with biorbital infiltration after 1 side exenteration. CONCLUSIONS: Orbital invasion may be clinically silent. Recurrence rate of BCC in our group 5% corresponds to date in the literature. The exenteration for BCC may be significantly higher when the lesion involves a medial canthal location and lower eyelid and initial surgery does not include margin-controlled excision.
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spelling pubmed-52664112017-02-08 Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit Furdova, Alena Lukacko, Pavol J Craniofac Surg Brief Clinical Studies PURPOSE: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the risk factors. DESIGN: Retrospective, comparative, interventional case series. METHODS: Data of all patients with BCC between 2008 and 2014 were reviewed for patient demographics, previous treatment options, tumor localization, and histopathologic subtype. RESULTS: In group of 256 patients, orbital exenteration underwent 7 patients (2.7%). For 2 patients (5.1%), orbital exenteration was the first procedure performed. In the exenterated group, the most common tumor site was the medial cantus and lower eyelid, whereas in the overall group, it was the lower eyelid (P = 0.011). The proportion of patients initially treated with histopathologic result of infiltration of 1 margin was significantly higher in patients undergoing exenteration (P = 0.282). During the 7-year period observership, the authors have seen 13 recurrences (5.08%). In patients with recurrent BCC after surgery, the authors applied adjuvant high dose rate (192)Ir brachytherapy. Neoadjuvant therapy with Vismodegib was effective in patient with biorbital infiltration after 1 side exenteration. CONCLUSIONS: Orbital invasion may be clinically silent. Recurrence rate of BCC in our group 5% corresponds to date in the literature. The exenteration for BCC may be significantly higher when the lesion involves a medial canthal location and lower eyelid and initial surgery does not include margin-controlled excision. Lippincott Williams & Wilkins 2017-01 2016-11-30 /pmc/articles/PMC5266411/ /pubmed/27906855 http://dx.doi.org/10.1097/SCS.0000000000003242 Text en Copyright © 2016 by Mutaz B. Habal, MD http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Brief Clinical Studies
Furdova, Alena
Lukacko, Pavol
Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title_full Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title_fullStr Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title_full_unstemmed Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title_short Periocular Basal Cell Carcinoma Predictors for Recurrence and Infiltration of the Orbit
title_sort periocular basal cell carcinoma predictors for recurrence and infiltration of the orbit
topic Brief Clinical Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266411/
https://www.ncbi.nlm.nih.gov/pubmed/27906855
http://dx.doi.org/10.1097/SCS.0000000000003242
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