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4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells

OBJECTIVES: Pancreatic ductal adenocarcinoma contains large amounts of the glycosaminoglycan hyaluronan (HA), which is involved in various physiological processes. Here, we aimed to clarify the anticancer mechanisms of 4-methylumbelliferone (MU), a well-known HA synthesis inhibitor. METHODS: MIA PaC...

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Detalles Bibliográficos
Autores principales:	Nagase, Hayato, Kudo, Daisuke, Suto, Akiko, Yoshida, Eri, Suto, Shinichiro, Negishi, Mika, Kakizaki, Ikuko, Hakamada, Kenichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266424/ https://www.ncbi.nlm.nih.gov/pubmed/27846148 http://dx.doi.org/10.1097/MPA.0000000000000741

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