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Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Usin...

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Autores principales: Pasquale, Louis R., Aschard, Hugues, Kang, Jae H., Bailey, Jessica N. Cooke, Lindström, Sara, Chasman, Daniel I., Christen, William G., Allingham, R. Rand, Ashley-Koch, Allison, Lee, Richard K., Moroi, Sayoko E., Brilliant, Murray H., Wollstein, Gadi, Schuman, Joel S., Fingert, John, Budenz, Donald L., Realini, Tony, Gaasterland, Terry, Gaasterland, Douglas, Scott, William K., Singh, Kuldev, Sit, Arthur J., Igo, Robert P., Song, Yeunjoo E., Hark, Lisa, Ritch, Robert, Rhee, Douglas J., Gulati, Vikas, Havens, Shane, Vollrath, Douglas, Zack, Donald J., Medeiros, Felipe, Weinreb, Robert N., Pericak-Vance, Margaret A., Liu, Yutao, Kraft, Peter, Richards, Julia E., Rosner, Bernard A., Hauser, Michael A., Haines, Jonathan L., Wiggs, Janey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott-Raven Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266624/
https://www.ncbi.nlm.nih.gov/pubmed/27760082
http://dx.doi.org/10.1097/GME.0000000000000741
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author Pasquale, Louis R.
Aschard, Hugues
Kang, Jae H.
Bailey, Jessica N. Cooke
Lindström, Sara
Chasman, Daniel I.
Christen, William G.
Allingham, R. Rand
Ashley-Koch, Allison
Lee, Richard K.
Moroi, Sayoko E.
Brilliant, Murray H.
Wollstein, Gadi
Schuman, Joel S.
Fingert, John
Budenz, Donald L.
Realini, Tony
Gaasterland, Terry
Gaasterland, Douglas
Scott, William K.
Singh, Kuldev
Sit, Arthur J.
Igo, Robert P.
Song, Yeunjoo E.
Hark, Lisa
Ritch, Robert
Rhee, Douglas J.
Gulati, Vikas
Havens, Shane
Vollrath, Douglas
Zack, Donald J.
Medeiros, Felipe
Weinreb, Robert N.
Pericak-Vance, Margaret A.
Liu, Yutao
Kraft, Peter
Richards, Julia E.
Rosner, Bernard A.
Hauser, Michael A.
Haines, Jonathan L.
Wiggs, Janey L.
author_facet Pasquale, Louis R.
Aschard, Hugues
Kang, Jae H.
Bailey, Jessica N. Cooke
Lindström, Sara
Chasman, Daniel I.
Christen, William G.
Allingham, R. Rand
Ashley-Koch, Allison
Lee, Richard K.
Moroi, Sayoko E.
Brilliant, Murray H.
Wollstein, Gadi
Schuman, Joel S.
Fingert, John
Budenz, Donald L.
Realini, Tony
Gaasterland, Terry
Gaasterland, Douglas
Scott, William K.
Singh, Kuldev
Sit, Arthur J.
Igo, Robert P.
Song, Yeunjoo E.
Hark, Lisa
Ritch, Robert
Rhee, Douglas J.
Gulati, Vikas
Havens, Shane
Vollrath, Douglas
Zack, Donald J.
Medeiros, Felipe
Weinreb, Robert N.
Pericak-Vance, Margaret A.
Liu, Yutao
Kraft, Peter
Richards, Julia E.
Rosner, Bernard A.
Hauser, Michael A.
Haines, Jonathan L.
Wiggs, Janey L.
author_sort Pasquale, Louis R.
collection PubMed
description OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Using data from the Nurses’ Health Study (7,143 women), we validated the ANM weighted genetic risk score in relation to self-reported ANM. Subsequently, to assess the relation with POAG, we used data from 2,160 female POAG cases and 29,110 controls in the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (NEIGHBORHOOD), which consists of 8 datasets with imputed genotypes to 5.6+ million markers. Associations with POAG were assessed in each dataset, and site-specific results were meta-analyzed using the inverse weighted variance method. RESULTS: The genetic risk score was associated with self-reported ANM (P = 2.2 × 10(–77)) and predicted 4.8% of the variance in ANM. The ANM genetic risk score was not associated with POAG (Odds Ratio (OR) = 1.002; 95% Confidence Interval (CI): 0.998, 1.007; P = 0.28). No single genetic variant in the panel achieved nominal association with POAG (P ≥0.20). Compared to the middle 80 percent, there was also no association with the lowest 10(th) percentile or highest 90(th) percentile of genetic risk score with POAG (OR = 0.75; 95% CI: 0.47, 1.21; P = 0.23 and OR = 1.10; 95% CI: 0.72, 1.69; P = 0.65, respectively). CONCLUSIONS: A genetic risk score predicting 4.8% of ANM variation was not related to POAG; thus, genetic determinants of ANM are unlikely to explain the previously reported association between the two phenotypes.
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spelling pubmed-52666242017-02-08 Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample Pasquale, Louis R. Aschard, Hugues Kang, Jae H. Bailey, Jessica N. Cooke Lindström, Sara Chasman, Daniel I. Christen, William G. Allingham, R. Rand Ashley-Koch, Allison Lee, Richard K. Moroi, Sayoko E. Brilliant, Murray H. Wollstein, Gadi Schuman, Joel S. Fingert, John Budenz, Donald L. Realini, Tony Gaasterland, Terry Gaasterland, Douglas Scott, William K. Singh, Kuldev Sit, Arthur J. Igo, Robert P. Song, Yeunjoo E. Hark, Lisa Ritch, Robert Rhee, Douglas J. Gulati, Vikas Havens, Shane Vollrath, Douglas Zack, Donald J. Medeiros, Felipe Weinreb, Robert N. Pericak-Vance, Margaret A. Liu, Yutao Kraft, Peter Richards, Julia E. Rosner, Bernard A. Hauser, Michael A. Haines, Jonathan L. Wiggs, Janey L. Menopause Original Articles OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Using data from the Nurses’ Health Study (7,143 women), we validated the ANM weighted genetic risk score in relation to self-reported ANM. Subsequently, to assess the relation with POAG, we used data from 2,160 female POAG cases and 29,110 controls in the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (NEIGHBORHOOD), which consists of 8 datasets with imputed genotypes to 5.6+ million markers. Associations with POAG were assessed in each dataset, and site-specific results were meta-analyzed using the inverse weighted variance method. RESULTS: The genetic risk score was associated with self-reported ANM (P = 2.2 × 10(–77)) and predicted 4.8% of the variance in ANM. The ANM genetic risk score was not associated with POAG (Odds Ratio (OR) = 1.002; 95% Confidence Interval (CI): 0.998, 1.007; P = 0.28). No single genetic variant in the panel achieved nominal association with POAG (P ≥0.20). Compared to the middle 80 percent, there was also no association with the lowest 10(th) percentile or highest 90(th) percentile of genetic risk score with POAG (OR = 0.75; 95% CI: 0.47, 1.21; P = 0.23 and OR = 1.10; 95% CI: 0.72, 1.69; P = 0.65, respectively). CONCLUSIONS: A genetic risk score predicting 4.8% of ANM variation was not related to POAG; thus, genetic determinants of ANM are unlikely to explain the previously reported association between the two phenotypes. Lippincott-Raven Publishers 2017-02 2017-01-26 /pmc/articles/PMC5266624/ /pubmed/27760082 http://dx.doi.org/10.1097/GME.0000000000000741 Text en Copyright © 2016 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The North American Menopause Society. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Original Articles
Pasquale, Louis R.
Aschard, Hugues
Kang, Jae H.
Bailey, Jessica N. Cooke
Lindström, Sara
Chasman, Daniel I.
Christen, William G.
Allingham, R. Rand
Ashley-Koch, Allison
Lee, Richard K.
Moroi, Sayoko E.
Brilliant, Murray H.
Wollstein, Gadi
Schuman, Joel S.
Fingert, John
Budenz, Donald L.
Realini, Tony
Gaasterland, Terry
Gaasterland, Douglas
Scott, William K.
Singh, Kuldev
Sit, Arthur J.
Igo, Robert P.
Song, Yeunjoo E.
Hark, Lisa
Ritch, Robert
Rhee, Douglas J.
Gulati, Vikas
Havens, Shane
Vollrath, Douglas
Zack, Donald J.
Medeiros, Felipe
Weinreb, Robert N.
Pericak-Vance, Margaret A.
Liu, Yutao
Kraft, Peter
Richards, Julia E.
Rosner, Bernard A.
Hauser, Michael A.
Haines, Jonathan L.
Wiggs, Janey L.
Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title_full Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title_fullStr Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title_full_unstemmed Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title_short Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample
title_sort age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a us-based sample
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266624/
https://www.ncbi.nlm.nih.gov/pubmed/27760082
http://dx.doi.org/10.1097/GME.0000000000000741
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