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Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is based on STAT tyrosine phosphorylation by activated JAKs. Downstream of interferon (IFN) receptors, activated JAKs cause the formation of the transcripti...

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Detalles Bibliográficos
Autores principales:	Majoros, Andrea, Platanitis, Ekaterini, Kernbauer-Hölzl, Elisabeth, Rosebrock, Felix, Müller, Mathias, Decker, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266721/ https://www.ncbi.nlm.nih.gov/pubmed/28184222 http://dx.doi.org/10.3389/fimmu.2017.00029

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