Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations

We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally wh...

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Detalles Bibliográficos
Autores principales: Hall, Julie M., Georgiades, Matthew J., Hammond, Deborah A., Feng, Xiaoting, Moustafa, Ahmed A., Lewis, Simon J. G., Todd, Gabrielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266844/
https://www.ncbi.nlm.nih.gov/pubmed/28168069
http://dx.doi.org/10.1155/2017/3673159
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author Hall, Julie M.
Georgiades, Matthew J.
Hammond, Deborah A.
Feng, Xiaoting
Moustafa, Ahmed A.
Lewis, Simon J. G.
Todd, Gabrielle
author_facet Hall, Julie M.
Georgiades, Matthew J.
Hammond, Deborah A.
Feng, Xiaoting
Moustafa, Ahmed A.
Lewis, Simon J. G.
Todd, Gabrielle
author_sort Hall, Julie M.
collection PubMed
description We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.
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spelling pubmed-52668442017-02-06 Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations Hall, Julie M. Georgiades, Matthew J. Hammond, Deborah A. Feng, Xiaoting Moustafa, Ahmed A. Lewis, Simon J. G. Todd, Gabrielle Case Rep Neurol Med Case Report We present clinical features and substantia nigra morphology for two brothers with Parkinson's disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD. Hindawi Publishing Corporation 2017 2017-01-11 /pmc/articles/PMC5266844/ /pubmed/28168069 http://dx.doi.org/10.1155/2017/3673159 Text en Copyright © 2017 Julie M. Hall et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hall, Julie M.
Georgiades, Matthew J.
Hammond, Deborah A.
Feng, Xiaoting
Moustafa, Ahmed A.
Lewis, Simon J. G.
Todd, Gabrielle
Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title_full Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title_fullStr Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title_full_unstemmed Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title_short Hyperechogenicity of the Substantia Nigra in Parkinson's Disease: Insights from Two Brothers with Markedly Different Disease Durations
title_sort hyperechogenicity of the substantia nigra in parkinson's disease: insights from two brothers with markedly different disease durations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266844/
https://www.ncbi.nlm.nih.gov/pubmed/28168069
http://dx.doi.org/10.1155/2017/3673159
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