In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1

Despite peptide transporter 1 (PEPT1) being responsible for the bioavailability for a variety of drugs, there has been little study of its potential involvement in drug-drug interactions. Pomaglumetad methionil, a metabotropic glutamate 2/3 receptor agonist prodrug, utilizes PEPT1 to enhance absorpt...

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Detalles Bibliográficos
Autores principales: Pak, Y. Anne, Long, Amanda J., Annes, William F., Witcher, Jennifer W., Knadler, Mary Pat, Ayan-Oshodi, Mosun A., Mitchell, Malcolm I., Leese, Phillip, Hillgren, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267515/
https://www.ncbi.nlm.nih.gov/pubmed/27895114
http://dx.doi.org/10.1124/dmd.116.071118

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