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Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach

Metabolism enzyme induction-mediated drug-drug interactions need to be carefully characterized in vitro for drug candidates to predict in vivo safety risk and therapeutic efficiency. Currently, both the Food and Drug Administration and European Medicines Agency recommend using primary human hepatocy...

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Detalles Bibliográficos
Autores principales:	Zuo, Rongjun, Li, Feng, Parikh, Sweta, Cao, Li, Cooper, Kirsten L., Hong, Yulong, Liu, Jin, Faris, Ronald A., Li, Daochuan, Wang, Hongbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267519/ https://www.ncbi.nlm.nih.gov/pubmed/28062541 http://dx.doi.org/10.1124/dmd.116.072124

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