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Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
BACKGROUND: Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. METHODS: AURKA protein ex...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pathologists and the Korean Society for Cytopathology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267544/ https://www.ncbi.nlm.nih.gov/pubmed/28013532 http://dx.doi.org/10.4132/jptm.2016.10.17 |
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author | Koh, Hyun Min Jang, Bo Geun Hyun, Chang Lim Kim, Young Sill Hyun, Jin Won Chang, Weon Young Maeng, Young Hee |
author_facet | Koh, Hyun Min Jang, Bo Geun Hyun, Chang Lim Kim, Young Sill Hyun, Jin Won Chang, Weon Young Maeng, Young Hee |
author_sort | Koh, Hyun Min |
collection | PubMed |
description | BACKGROUND: Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. METHODS: AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues. RESULTS: AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001). CONCLUSIONS: AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients. |
format | Online Article Text |
id | pubmed-5267544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Society of Pathologists and the Korean Society for Cytopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-52675442017-02-06 Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma Koh, Hyun Min Jang, Bo Geun Hyun, Chang Lim Kim, Young Sill Hyun, Jin Won Chang, Weon Young Maeng, Young Hee J Pathol Transl Med Original Article BACKGROUND: Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. METHODS: AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues. RESULTS: AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001). CONCLUSIONS: AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients. The Korean Society of Pathologists and the Korean Society for Cytopathology 2017-01 2016-12-25 /pmc/articles/PMC5267544/ /pubmed/28013532 http://dx.doi.org/10.4132/jptm.2016.10.17 Text en © 2017 The Korean Society of Pathologists/The Korean Society for Cytopathology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Koh, Hyun Min Jang, Bo Geun Hyun, Chang Lim Kim, Young Sill Hyun, Jin Won Chang, Weon Young Maeng, Young Hee Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title | Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title_full | Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title_fullStr | Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title_full_unstemmed | Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title_short | Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma |
title_sort | aurora kinase a is a prognostic marker in colorectal adenocarcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267544/ https://www.ncbi.nlm.nih.gov/pubmed/28013532 http://dx.doi.org/10.4132/jptm.2016.10.17 |
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