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Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering
Silicon-based mesoporous nanoparticles have been extensively studied to meet the challenges in the drug delivery. Functionality of these nanoparticles depends on their properties which are often changing as a function of particle size and surrounding medium. Widely used characterization methods, dyn...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267583/ https://www.ncbi.nlm.nih.gov/pubmed/28124301 http://dx.doi.org/10.1186/s11671-017-1853-y |
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author | Kaasalainen, Martti Aseyev, Vladimir von Haartman, Eva Karaman, Didem Şen Mäkilä, Ermei Tenhu, Heikki Rosenholm, Jessica Salonen, Jarno |
author_facet | Kaasalainen, Martti Aseyev, Vladimir von Haartman, Eva Karaman, Didem Şen Mäkilä, Ermei Tenhu, Heikki Rosenholm, Jessica Salonen, Jarno |
author_sort | Kaasalainen, Martti |
collection | PubMed |
description | Silicon-based mesoporous nanoparticles have been extensively studied to meet the challenges in the drug delivery. Functionality of these nanoparticles depends on their properties which are often changing as a function of particle size and surrounding medium. Widely used characterization methods, dynamic light scattering (DLS), and transmission electron microscope (TEM) have both their weaknesses. We hypothesize that conventional light scattering (LS) methods can be used for a rigorous characterization of medium sensitive nanoparticles’ properties, like size, stability, and porosity. Two fundamentally different silicon-based nanoparticles were made: porous silicon (PSi) from crystalline silicon and silica nanoparticles (SN) through sol-gel process. We studied the properties of these mesoporous nanoparticles with two different multiangle LS techniques, DLS and static light scattering (SLS), and compared the results to dry-state techniques, TEM, and nitrogen sorption. Comparison of particle radius from TEM and DLS revealed significant overestimation of the DLS result. Regarding to silica nanoparticles, the overestimation was attributed to agglomeration by analyzing radius of gyration and hydrodynamic radius. In case of PSi nanoparticles, strong correlation between LS result and specific surface area was found. Our results suggest that the multiangle LS methods could be used for the size, stability, and structure characterization of mesoporous nanoparticles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-017-1853-y) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5267583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-52675832017-02-09 Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering Kaasalainen, Martti Aseyev, Vladimir von Haartman, Eva Karaman, Didem Şen Mäkilä, Ermei Tenhu, Heikki Rosenholm, Jessica Salonen, Jarno Nanoscale Res Lett Nano Express Silicon-based mesoporous nanoparticles have been extensively studied to meet the challenges in the drug delivery. Functionality of these nanoparticles depends on their properties which are often changing as a function of particle size and surrounding medium. Widely used characterization methods, dynamic light scattering (DLS), and transmission electron microscope (TEM) have both their weaknesses. We hypothesize that conventional light scattering (LS) methods can be used for a rigorous characterization of medium sensitive nanoparticles’ properties, like size, stability, and porosity. Two fundamentally different silicon-based nanoparticles were made: porous silicon (PSi) from crystalline silicon and silica nanoparticles (SN) through sol-gel process. We studied the properties of these mesoporous nanoparticles with two different multiangle LS techniques, DLS and static light scattering (SLS), and compared the results to dry-state techniques, TEM, and nitrogen sorption. Comparison of particle radius from TEM and DLS revealed significant overestimation of the DLS result. Regarding to silica nanoparticles, the overestimation was attributed to agglomeration by analyzing radius of gyration and hydrodynamic radius. In case of PSi nanoparticles, strong correlation between LS result and specific surface area was found. Our results suggest that the multiangle LS methods could be used for the size, stability, and structure characterization of mesoporous nanoparticles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11671-017-1853-y) contains supplementary material, which is available to authorized users. Springer US 2017-01-25 /pmc/articles/PMC5267583/ /pubmed/28124301 http://dx.doi.org/10.1186/s11671-017-1853-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Nano Express Kaasalainen, Martti Aseyev, Vladimir von Haartman, Eva Karaman, Didem Şen Mäkilä, Ermei Tenhu, Heikki Rosenholm, Jessica Salonen, Jarno Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title | Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title_full | Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title_fullStr | Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title_full_unstemmed | Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title_short | Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering |
title_sort | size, stability, and porosity of mesoporous nanoparticles characterized with light scattering |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267583/ https://www.ncbi.nlm.nih.gov/pubmed/28124301 http://dx.doi.org/10.1186/s11671-017-1853-y |
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