Structural basis for the in vitro known acyl-depsipeptide 2 (ADEP2) inhibition to Clp 2 protease from Mycobacterium tuberculosis

Inhibition of Mycobacterium tuberculosis Clp 2 protease has emerged as an attractive therapeutic option for treatment. Acyldepsipeptides (ADEPs) is known as an inhibitor for Clp 2 protease. Therefore, it is of interest to document its affinity, enzyme activity and ADME profiles. We report the predic...

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Detalles Bibliográficos
Autores principales: Khandekar, Natasha, Singh, Snehal, Shukla, Ruchi, Tirumalaraju, Sridevi, Bandaru, Srinivas, Banerjee, Tushar, Nayarisseri, Anuraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2016
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267950/
https://www.ncbi.nlm.nih.gov/pubmed/28149041
http://dx.doi.org/10.6026/97320630012092

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