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Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy

Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related...

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Autores principales: Arooj, Mahwish, Malik, Arif, Basit, Abdul, Husain Qazi, Mahmood, Asif, Muhammad, Sarwar Jamal, Mohammad, Mostafa Mahmoud, Maged, Choudhry, Hani, Natesan Pushparaj, Peter, Rasool, Mahmood
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267956/
https://www.ncbi.nlm.nih.gov/pubmed/28149047
http://dx.doi.org/10.6026/97320630012131
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author Arooj, Mahwish
Malik, Arif
Basit, Abdul
Husain Qazi, Mahmood
Asif, Muhammad
Sarwar Jamal, Mohammad
Mostafa Mahmoud, Maged
Choudhry, Hani
Natesan Pushparaj, Peter
Rasool, Mahmood
author_facet Arooj, Mahwish
Malik, Arif
Basit, Abdul
Husain Qazi, Mahmood
Asif, Muhammad
Sarwar Jamal, Mohammad
Mostafa Mahmoud, Maged
Choudhry, Hani
Natesan Pushparaj, Peter
Rasool, Mahmood
author_sort Arooj, Mahwish
collection PubMed
description Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls. The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody (TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders.
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spelling pubmed-52679562017-02-01 Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy Arooj, Mahwish Malik, Arif Basit, Abdul Husain Qazi, Mahmood Asif, Muhammad Sarwar Jamal, Mohammad Mostafa Mahmoud, Maged Choudhry, Hani Natesan Pushparaj, Peter Rasool, Mahmood Bioinformation Hypothesis Systematic administration of interferon-alpha (INF-alpha) is considered as the backbone of HCV therapy since 1991. Interferon (IFN) therapy can cause vasculitis, glomerulonephritis, cryoglobulinemia and certain other autoimmune diseases such as sialoadentitis, lichen planus and thyroiditis. Related to the factors of interferons, extensively studied gland is thyroid gland. A strong association was observed between thyroid disease and HCV patient when they were exposed to IFN therapy. Vitamin D, malondialdehyde (MDA), thyroid hormones and auto antibodies were biochemically assessed from the venous blood of seventy five HCV patients and fifty healthy controls. The results of all parameters were analyzed by independent sample t-test. The results of the study demonstrated a clear picture that the levels of vitamin D decreased as compared to control but increases in case of MDA. The levels of antibody titer represent that thyroglobulin-antibody (TGAb) thyroid peroxidase-antibody (TPOAb) as well as thyroid stimulating hormone receptor-antibody (TSHRAb) were raised in the patients suffering from HCV with thyroid dysfunction as compared to control. Similarly, the levels of thyroid hormones were also elevated in the HCV patients. Antibodies generated against thyroidal enzymes leads to impaired function of these enzymes thus causing decreased synthesis of thyroid hormones. As exogenous INF triggers the release of cytokines that mediate the recruitment of immune cells with increased production of inflammatory markers lead to production of lytic granules which have direct toxic action on thyroid cells and ultimately increased lipid peroxidation of thyrocytes. The results of the present study clearly demonstrated that the decreased levels of vitamin D in HCV patients receiving IFN therapy were responsible to induce autoimmunity against thyroid gland and adjutant therapy may be helpful to alleviate the possible thyroid disorders. Biomedical Informatics 2016-06-15 /pmc/articles/PMC5267956/ /pubmed/28149047 http://dx.doi.org/10.6026/97320630012131 Text en © 2016 Biomedical Informatics This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Hypothesis
Arooj, Mahwish
Malik, Arif
Basit, Abdul
Husain Qazi, Mahmood
Asif, Muhammad
Sarwar Jamal, Mohammad
Mostafa Mahmoud, Maged
Choudhry, Hani
Natesan Pushparaj, Peter
Rasool, Mahmood
Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title_full Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title_fullStr Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title_full_unstemmed Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title_short Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy
title_sort implications of prognostic variables in the assessment of autoimmunity in hepatitis c patients receiving interferon therapy
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267956/
https://www.ncbi.nlm.nih.gov/pubmed/28149047
http://dx.doi.org/10.6026/97320630012131
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