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Molecular mechanisms and mode of tamoxifen resistance in breast cancer
Breast cancer is one of the most common cancers in women around the globe Tamoxifen is used for the last 40 years as an endocrine therapy for breast cancer. This resulted in the reduction of mortality rate by 30% and it still remains one of the most effective therapies against breast cancer. However...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267957/ https://www.ncbi.nlm.nih.gov/pubmed/28149048 http://dx.doi.org/10.6026/97320630012135 |
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author | Ali, Shazia Rasool, Mahmood Chaoudhry, Hani N Pushparaj, Peter Jha, Prakash Hafiz, Abdul Mahfooz, Maryam Abdus Sami, Ghufrana Azhar Kamal, Mohammad Bashir, Sania Ali, Ashraf Sarwar Jamal, Mohammad |
author_facet | Ali, Shazia Rasool, Mahmood Chaoudhry, Hani N Pushparaj, Peter Jha, Prakash Hafiz, Abdul Mahfooz, Maryam Abdus Sami, Ghufrana Azhar Kamal, Mohammad Bashir, Sania Ali, Ashraf Sarwar Jamal, Mohammad |
author_sort | Ali, Shazia |
collection | PubMed |
description | Breast cancer is one of the most common cancers in women around the globe Tamoxifen is used for the last 40 years as an endocrine therapy for breast cancer. This resulted in the reduction of mortality rate by 30% and it still remains one of the most effective therapies against breast cancer. However, resistance against tamoxifen is still one of the major hurdles in the effective management of breast cancer. Intense research has been conducted in the past decade to further explore its resistance mechanism, but still a lot of research will be needed to effectively alleviate this problem. Several biochemical factors and molecular pathways, such as the modulation of ER signaling, upregulation of growth factors had been observed as key factors for tamoxifen resistance (TR). After, initial therapy of five to ten years, breast cancer patients develops resistance towards this drug. The resistance leads to the development of other cancers like uterine cancer. Here, we briefly explore all the molecular events related to tamoxifen resistance and focus on its mechanism of action as well as other pharmacological approaches to better its beneficial effects in the treatment of breast carcinoma. |
format | Online Article Text |
id | pubmed-5267957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-52679572017-02-01 Molecular mechanisms and mode of tamoxifen resistance in breast cancer Ali, Shazia Rasool, Mahmood Chaoudhry, Hani N Pushparaj, Peter Jha, Prakash Hafiz, Abdul Mahfooz, Maryam Abdus Sami, Ghufrana Azhar Kamal, Mohammad Bashir, Sania Ali, Ashraf Sarwar Jamal, Mohammad Bioinformation Review Breast cancer is one of the most common cancers in women around the globe Tamoxifen is used for the last 40 years as an endocrine therapy for breast cancer. This resulted in the reduction of mortality rate by 30% and it still remains one of the most effective therapies against breast cancer. However, resistance against tamoxifen is still one of the major hurdles in the effective management of breast cancer. Intense research has been conducted in the past decade to further explore its resistance mechanism, but still a lot of research will be needed to effectively alleviate this problem. Several biochemical factors and molecular pathways, such as the modulation of ER signaling, upregulation of growth factors had been observed as key factors for tamoxifen resistance (TR). After, initial therapy of five to ten years, breast cancer patients develops resistance towards this drug. The resistance leads to the development of other cancers like uterine cancer. Here, we briefly explore all the molecular events related to tamoxifen resistance and focus on its mechanism of action as well as other pharmacological approaches to better its beneficial effects in the treatment of breast carcinoma. Biomedical Informatics 2016-06-15 /pmc/articles/PMC5267957/ /pubmed/28149048 http://dx.doi.org/10.6026/97320630012135 Text en © 2016 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Review Ali, Shazia Rasool, Mahmood Chaoudhry, Hani N Pushparaj, Peter Jha, Prakash Hafiz, Abdul Mahfooz, Maryam Abdus Sami, Ghufrana Azhar Kamal, Mohammad Bashir, Sania Ali, Ashraf Sarwar Jamal, Mohammad Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title | Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title_full | Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title_fullStr | Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title_full_unstemmed | Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title_short | Molecular mechanisms and mode of tamoxifen resistance in breast cancer |
title_sort | molecular mechanisms and mode of tamoxifen resistance in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267957/ https://www.ncbi.nlm.nih.gov/pubmed/28149048 http://dx.doi.org/10.6026/97320630012135 |
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