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Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections

PURPOSE: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. METHODS: This study is a...

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Autores principales: Levin, Ariana M, Rusu, Irene, Orlin, Anton, Gupta, Mrinali P, Coombs, Peter, D’Amico, Donald J, Kiss, Szilárd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268366/
https://www.ncbi.nlm.nih.gov/pubmed/28176934
http://dx.doi.org/10.2147/OPTH.S118807
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author Levin, Ariana M
Rusu, Irene
Orlin, Anton
Gupta, Mrinali P
Coombs, Peter
D’Amico, Donald J
Kiss, Szilárd
author_facet Levin, Ariana M
Rusu, Irene
Orlin, Anton
Gupta, Mrinali P
Coombs, Peter
D’Amico, Donald J
Kiss, Szilárd
author_sort Levin, Ariana M
collection PubMed
description PURPOSE: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. METHODS: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. RESULTS: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. CONCLUSION: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA.
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spelling pubmed-52683662017-02-07 Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections Levin, Ariana M Rusu, Irene Orlin, Anton Gupta, Mrinali P Coombs, Peter D’Amico, Donald J Kiss, Szilárd Clin Ophthalmol Original Research PURPOSE: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. METHODS: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images. Images were analyzed for reperfusion qualitatively and quantitatively by two graders. RESULTS: Twelve of 16 eyes (75%) or 11 of 15 patients (73.3%) demonstrated reperfusion following anti-VEGF injection. On UWFA, reperfusion was detected both within the field of 7-standard field (7SF) fluorescein angiography and in the periphery outside the 7SF. Four of 16 eyes or 4 of 15 patients did not demonstrate reperfusion, one of which had extensive scarring from prior panretinal photocoagulation. CONCLUSION: In patients with diabetic retinopathy, treatment with anti-VEGF agents can be associated with reperfusion of areas of nonperfusion, as demonstrated by UWFA. Dove Medical Press 2017-01-21 /pmc/articles/PMC5268366/ /pubmed/28176934 http://dx.doi.org/10.2147/OPTH.S118807 Text en © 2017 Levin et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Levin, Ariana M
Rusu, Irene
Orlin, Anton
Gupta, Mrinali P
Coombs, Peter
D’Amico, Donald J
Kiss, Szilárd
Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_full Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_fullStr Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_full_unstemmed Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_short Retinal reperfusion in diabetic retinopathy following treatment with anti-VEGF intravitreal injections
title_sort retinal reperfusion in diabetic retinopathy following treatment with anti-vegf intravitreal injections
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268366/
https://www.ncbi.nlm.nih.gov/pubmed/28176934
http://dx.doi.org/10.2147/OPTH.S118807
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