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Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age

Conventional magnetic resonance imaging (MRI) at term equivalent age (TEA) is suggested to be a reliable tool to predict the outcome of very premature infants. The objective of this study was to determine simple reproducible MRI indices, in premature infants and to analyze their neonatal determinant...

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Autores principales: Naud, Aurelie, Schmitt, Emmanuelle, Wirth, Maelle, Hascoet, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268368/
https://www.ncbi.nlm.nih.gov/pubmed/28125676
http://dx.doi.org/10.1371/journal.pone.0170797
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author Naud, Aurelie
Schmitt, Emmanuelle
Wirth, Maelle
Hascoet, Jean-Michel
author_facet Naud, Aurelie
Schmitt, Emmanuelle
Wirth, Maelle
Hascoet, Jean-Michel
author_sort Naud, Aurelie
collection PubMed
description Conventional magnetic resonance imaging (MRI) at term equivalent age (TEA) is suggested to be a reliable tool to predict the outcome of very premature infants. The objective of this study was to determine simple reproducible MRI indices, in premature infants and to analyze their neonatal determinants at TEA. A cohort of infants born before 32 weeks gestational age (GA) underwent a MRI at TEA in our center. Two axial images (T2 weighted), were chosen to realize nine measures. We defined 4 linear indices (MAfhlv: thickness of lateral ventricle; CSI: cortex-skull index; VCI: ventricular-cortex index; BOI: bi occipital index) and 1 surface index (VS.A: volume slice area). Perinatal data were recorded. Sixty-nine infants had a GA (median (interquartile range)) of 30.0 weeks GA (27.0; 30.0) and a birth weight of 1240 grams (986; 1477). MRI was done at 41.0 (40.0; 42.0) weeks post menstrual age (PMA). The inter-investigator reproducibility was good. Twenty one MRI (30.5%) were quoted abnormal. We observed an association with retinopathy of prematurity (OR [95CI] = 4.205 [1.231–14.368]; p = 0.017), surgery for patent ductus arteriosus (OR = 4.688 [1.01–21.89]; p = 0.036), early onset infection (OR = 4.688 [1.004–21.889]; p = 0.036) and neonatal treatment by cefotaxime (OR = 3.222 [1.093–9.497]; p = 0.03). There was a difference for VCI between normal and abnormal MRI (0.412 (0.388; 0.429) vs. 0.432 (0.418; 0.449); p = 0,019); BOI was higher when fossa posterior lesions were observed; VS.A seems to be the best surrogate for cerebral volume, 80% of VS.As’ variance being explained by a multiple linear regression model including 7 variables (head circumference at birth and at TEA, PMA, dopamine, ibuprofen treatment, blood and platelets transfusions). These indices, easily and rapidly achievable, seem to be useful but need to be validated in a large population to allow generalization for diagnosis and follow-up of former premature infants.
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spelling pubmed-52683682017-02-06 Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age Naud, Aurelie Schmitt, Emmanuelle Wirth, Maelle Hascoet, Jean-Michel PLoS One Research Article Conventional magnetic resonance imaging (MRI) at term equivalent age (TEA) is suggested to be a reliable tool to predict the outcome of very premature infants. The objective of this study was to determine simple reproducible MRI indices, in premature infants and to analyze their neonatal determinants at TEA. A cohort of infants born before 32 weeks gestational age (GA) underwent a MRI at TEA in our center. Two axial images (T2 weighted), were chosen to realize nine measures. We defined 4 linear indices (MAfhlv: thickness of lateral ventricle; CSI: cortex-skull index; VCI: ventricular-cortex index; BOI: bi occipital index) and 1 surface index (VS.A: volume slice area). Perinatal data were recorded. Sixty-nine infants had a GA (median (interquartile range)) of 30.0 weeks GA (27.0; 30.0) and a birth weight of 1240 grams (986; 1477). MRI was done at 41.0 (40.0; 42.0) weeks post menstrual age (PMA). The inter-investigator reproducibility was good. Twenty one MRI (30.5%) were quoted abnormal. We observed an association with retinopathy of prematurity (OR [95CI] = 4.205 [1.231–14.368]; p = 0.017), surgery for patent ductus arteriosus (OR = 4.688 [1.01–21.89]; p = 0.036), early onset infection (OR = 4.688 [1.004–21.889]; p = 0.036) and neonatal treatment by cefotaxime (OR = 3.222 [1.093–9.497]; p = 0.03). There was a difference for VCI between normal and abnormal MRI (0.412 (0.388; 0.429) vs. 0.432 (0.418; 0.449); p = 0,019); BOI was higher when fossa posterior lesions were observed; VS.A seems to be the best surrogate for cerebral volume, 80% of VS.As’ variance being explained by a multiple linear regression model including 7 variables (head circumference at birth and at TEA, PMA, dopamine, ibuprofen treatment, blood and platelets transfusions). These indices, easily and rapidly achievable, seem to be useful but need to be validated in a large population to allow generalization for diagnosis and follow-up of former premature infants. Public Library of Science 2017-01-26 /pmc/articles/PMC5268368/ /pubmed/28125676 http://dx.doi.org/10.1371/journal.pone.0170797 Text en © 2017 Naud et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Naud, Aurelie
Schmitt, Emmanuelle
Wirth, Maelle
Hascoet, Jean-Michel
Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title_full Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title_fullStr Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title_full_unstemmed Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title_short Determinants of Indices of Cerebral Volume in Former Very Premature Infants at Term Equivalent Age
title_sort determinants of indices of cerebral volume in former very premature infants at term equivalent age
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268368/
https://www.ncbi.nlm.nih.gov/pubmed/28125676
http://dx.doi.org/10.1371/journal.pone.0170797
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