Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains

Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed world. The main virulence factors of the bacterium are the large clostridial toxins (LCTs), TcdA and TcdB, which are largely responsible for the symptoms of the disease. Recent outbreaks of CDI have be...

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Detalles Bibliográficos
Autores principales: Secore, Susan, Wang, Su, Doughtry, Julie, Xie, Jinfu, Miezeiewski, Matt, Rustandi, Richard R., Horton, Melanie, Xoconostle, Rachel, Wang, Bei, Lancaster, Catherine, Kristopeit, Adam, Wang, Sheng-Ching, Christanti, Sianny, Vitelli, Salvatore, Gentile, Marie-Pierre, Goerke, Aaron, Skinner, Julie, Strable, Erica, Thiriot, David S., Bodmer, Jean-Luc, Heinrichs, Jon H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268477/
https://www.ncbi.nlm.nih.gov/pubmed/28125650
http://dx.doi.org/10.1371/journal.pone.0170640

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