Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels

Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Eun Ji, Jeon, Seong Gak, Kim, Kyoung Ah, Kim, Jin-il, Moon, Minho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268764/
https://www.ncbi.nlm.nih.gov/pubmed/28229084
http://dx.doi.org/10.1080/23262133.2016.1256856
_version_ 1782500877317177344
author Song, Eun Ji
Jeon, Seong Gak
Kim, Kyoung Ah
Kim, Jin-il
Moon, Minho
author_facet Song, Eun Ji
Jeon, Seong Gak
Kim, Kyoung Ah
Kim, Jin-il
Moon, Minho
author_sort Song, Eun Ji
collection PubMed
description Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice.
format Online
Article
Text
id pubmed-5268764
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-52687642018-01-05 Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels Song, Eun Ji Jeon, Seong Gak Kim, Kyoung Ah Kim, Jin-il Moon, Minho Neurogenesis (Austin) Commentary Despite the effects of CD4+ T cell dysfunction on cognitive and behavioral impairment are well established, the effects of Th2 cytokines on the adult hippocampal neurogenesis and cognitive function in restricted CD4+ T cell receptor (TCR) repertoire model have not been fully elucidate. We found that mice with restricted CD4+ repertoire TCR showed decreased adult hippocampal neurogenesis using OT-II mice. Moreover, we demonstrated that OT-II mice showed increased Th2 cytokine levels in peripheral organs and IL-4 levels in brain. Taken together, altered Th2 cytokine levels may impact learning and memory via impaired adult neurogenesis in restricted CD4+ repertoire TCR mice. Taylor & Francis 2017-01-05 /pmc/articles/PMC5268764/ /pubmed/28229084 http://dx.doi.org/10.1080/23262133.2016.1256856 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Song, Eun Ji
Jeon, Seong Gak
Kim, Kyoung Ah
Kim, Jin-il
Moon, Minho
Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title_full Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title_fullStr Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title_full_unstemmed Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title_short Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels
title_sort restricted cd4+ t cell receptor repertoire impairs cognitive function via alteration of th2 cytokine levels
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268764/
https://www.ncbi.nlm.nih.gov/pubmed/28229084
http://dx.doi.org/10.1080/23262133.2016.1256856
work_keys_str_mv AT songeunji restrictedcd4tcellreceptorrepertoireimpairscognitivefunctionviaalterationofth2cytokinelevels
AT jeonseonggak restrictedcd4tcellreceptorrepertoireimpairscognitivefunctionviaalterationofth2cytokinelevels
AT kimkyoungah restrictedcd4tcellreceptorrepertoireimpairscognitivefunctionviaalterationofth2cytokinelevels
AT kimjinil restrictedcd4tcellreceptorrepertoireimpairscognitivefunctionviaalterationofth2cytokinelevels
AT moonminho restrictedcd4tcellreceptorrepertoireimpairscognitivefunctionviaalterationofth2cytokinelevels

Ejemplares similares