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Differences in Vector Genome Processing and Illegitimate Integration of Non-Integrating Lentiviral Vectors
A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-LTR integrase attachment site deletion (U3-LTR att site) mutant and found similar physical titers to the previously reported integrase catalytic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269419/ https://www.ncbi.nlm.nih.gov/pubmed/27682478 http://dx.doi.org/10.1038/gt.2016.69 |