Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications

Recent hemophilia B clinical trials using adeno-associated virus (AAV) gene delivery have demonstrated much lower FIX production in patients compared to the high levels observed in animal models and AAV capsid specific CTLs response elicited at high doses of AAV vectors. These results emphasize the...

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Detalles Bibliográficos
Autores principales: Wang, Mei, Sun, Junjiang, Crosby, Ashley, Woodard, Kenton, Hirsch, Matthew L., Samulski, R. Jude, Li, Chengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269444/
https://www.ncbi.nlm.nih.gov/pubmed/27834949
http://dx.doi.org/10.1038/gt.2016.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269444/
https://www.ncbi.nlm.nih.gov/pubmed/27834949
http://dx.doi.org/10.1038/gt.2016.75

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