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Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine
Precision medicine with molecularly directed therapeutics is rapidly expanding in all subspecialties of oncology. Molecular analysis and treatment monitoring require tumor tissue, but resections or biopsies are not always feasible due to tumor location, patient safety, and cost. Circulating tumor ce...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269447/ https://www.ncbi.nlm.nih.gov/pubmed/28191452 http://dx.doi.org/10.3389/fonc.2017.00006 |
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author | Hugen, Cory M. Zainfeld, Daniel E. Goldkorn, Amir |
author_facet | Hugen, Cory M. Zainfeld, Daniel E. Goldkorn, Amir |
author_sort | Hugen, Cory M. |
collection | PubMed |
description | Precision medicine with molecularly directed therapeutics is rapidly expanding in all subspecialties of oncology. Molecular analysis and treatment monitoring require tumor tissue, but resections or biopsies are not always feasible due to tumor location, patient safety, and cost. Circulating tumor cells (CTCs) offer a safe, low-cost, and repeatable tissue source as an alternative to invasive biopsies. “Liquid biopsies” can be collected from a peripheral blood draw and analyzed to isolate, enumerate, and molecularly characterize CTCs. While there is deserved excitement surrounding new CTC technologies, studies are ongoing to determine whether these cells can provide reliable and accurate information about molecular drivers of cancer progression and inform treatment decisions. This review focuses on the current status of CTCs in genitourinary (GU) cancer. We will review currently used methodologies to isolate and detect CTCs, their use as predictive biomarkers, and highlight emerging research and applications of CTC analysis in GU malignancies. |
format | Online Article Text |
id | pubmed-5269447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52694472017-02-10 Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine Hugen, Cory M. Zainfeld, Daniel E. Goldkorn, Amir Front Oncol Oncology Precision medicine with molecularly directed therapeutics is rapidly expanding in all subspecialties of oncology. Molecular analysis and treatment monitoring require tumor tissue, but resections or biopsies are not always feasible due to tumor location, patient safety, and cost. Circulating tumor cells (CTCs) offer a safe, low-cost, and repeatable tissue source as an alternative to invasive biopsies. “Liquid biopsies” can be collected from a peripheral blood draw and analyzed to isolate, enumerate, and molecularly characterize CTCs. While there is deserved excitement surrounding new CTC technologies, studies are ongoing to determine whether these cells can provide reliable and accurate information about molecular drivers of cancer progression and inform treatment decisions. This review focuses on the current status of CTCs in genitourinary (GU) cancer. We will review currently used methodologies to isolate and detect CTCs, their use as predictive biomarkers, and highlight emerging research and applications of CTC analysis in GU malignancies. Frontiers Media S.A. 2017-01-27 /pmc/articles/PMC5269447/ /pubmed/28191452 http://dx.doi.org/10.3389/fonc.2017.00006 Text en Copyright © 2017 Hugen, Zainfeld and Goldkorn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hugen, Cory M. Zainfeld, Daniel E. Goldkorn, Amir Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title | Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title_full | Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title_fullStr | Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title_full_unstemmed | Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title_short | Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine |
title_sort | circulating tumor cells in genitourinary malignancies: an evolving path to precision medicine |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269447/ https://www.ncbi.nlm.nih.gov/pubmed/28191452 http://dx.doi.org/10.3389/fonc.2017.00006 |
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