PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2

The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor...

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Detalles Bibliográficos
Autores principales: Dong, H, Ma, L, Gan, J, Lin, W, Chen, C, Yao, Z, Du, L, Zheng, L, Ke, C, Huang, X, Song, H, Kumar, R, Yeung, S C, Zhang, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269534/
https://www.ncbi.nlm.nih.gov/pubmed/27345410
http://dx.doi.org/10.1038/onc.2016.213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269534/
https://www.ncbi.nlm.nih.gov/pubmed/27345410
http://dx.doi.org/10.1038/onc.2016.213

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