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PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2

The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor...

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Detalles Bibliográficos
Autores principales:	Dong, H, Ma, L, Gan, J, Lin, W, Chen, C, Yao, Z, Du, L, Zheng, L, Ke, C, Huang, X, Song, H, Kumar, R, Yeung, S C, Zhang, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269534/ https://www.ncbi.nlm.nih.gov/pubmed/27345410 http://dx.doi.org/10.1038/onc.2016.213

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