p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

Aberrant p62 overexpression has been implicated in breast cancer development. Here, we found that p62 expression was elevated in breast cancer stem cells (BCSCs), including CD44(+)CD24(−) fractions, mammospheres, ALDH1(+) populations and side population cells. Indeed, short-hairpin RNA (shRNA)-media...

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Detalles Bibliográficos
Autores principales: Xu, L-Z, Li, S-S, Zhou, W, Kang, Z-J, Zhang, Q-X, Kamran, M, Xu, J, Liang, D-P, Wang, C-L, Hou, Z-J, Wan, X-B, Wang, H-J, Lam, E W-F, Zhao, Z-W, Liu, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269535/
https://www.ncbi.nlm.nih.gov/pubmed/27345399
http://dx.doi.org/10.1038/onc.2016.202

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