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Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis
The underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly expressed CKIP-1 together with lowly expressed total and phosphorylated Smad1/5 in bone samples was accompanied by either the red...
Autores principales: | Liu, Jin, Lu, Changwei, Wu, Xiaohao, Zhang, Zongkang, Li, Jie, Guo, Baosheng, Li, Defang, Liang, Chao, Dang, Lei, Pan, Xiaohua, Peng, Songlin, Lu, Aiping, Zhang, Baoting, Zhang, Ge |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269586/ https://www.ncbi.nlm.nih.gov/pubmed/28128304 http://dx.doi.org/10.1038/srep41295 |
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