Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells

The actin cytoskeleton is an attractive target for bacterial toxins. The ADP-ribosyltransferase TccC3 from the insect bacterial pathogen Photorhabdus luminescence modifies actin to force its aggregation. We intended to transport the catalytic part of this toxin preferentially into cancer cells using...

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Detalles Bibliográficos
Autores principales: Zahaf , N.-I., Lang, A. E., Kaiser, L., Fichter, C. D., Lassmann, S., McCluskey, A., Augspach, A., Aktories, K., Schmidt, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269596/
https://www.ncbi.nlm.nih.gov/pubmed/28128281
http://dx.doi.org/10.1038/srep41252

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