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Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways

Interleukin (IL)-6 is known to indirectly enhance osteoclast formation by promoting receptor activator of nuclear factor kappa-B ligand (RANKL) production by osteoblastic/stromal cells. However, little is known about the direct effect of IL-6 on osteoclastogenesis. Here, we determined the direct eff...

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Detalles Bibliográficos
Autores principales:	Feng, Wei, Liu, Hongrui, Luo, Tingting, Liu, Di, Du, Juan, Sun, Jing, Wang, Wei, Han, Xiuchun, Yang, Kaiyun, Guo, Jie, Amizuka, Norio, Li, Minqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269740/ https://www.ncbi.nlm.nih.gov/pubmed/28128332 http://dx.doi.org/10.1038/srep41411

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