RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis

The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is affected by seizures in vivo and whether changes confer beneficial or maladaptive responses that influence long-term outcomes su...

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Detalles Bibliográficos
Autores principales: Mooney, Claire M., Jimenez-Mateos, Eva M., Engel, Tobias, Mooney, Catherine, Diviney, Mairead, Venø, Morten T., Kjems, Jørgen, Farrell, Michael A., O’Brien, Donncha F., Delanty, Norman, Henshall, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269742/
https://www.ncbi.nlm.nih.gov/pubmed/28128343
http://dx.doi.org/10.1038/srep41517

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