Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status

BACKGROUND: The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Morocca...

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Autores principales: Ezzikouri, Sayeh, Chihab, Hajar, Elhabazi, Abdellah, Wakrim, Lahcen, Benjelloun, Soumaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270288/
https://www.ncbi.nlm.nih.gov/pubmed/28125961
http://dx.doi.org/10.1186/s12879-017-2214-2
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author Ezzikouri, Sayeh
Chihab, Hajar
Elhabazi, Abdellah
Wakrim, Lahcen
Benjelloun, Soumaya
author_facet Ezzikouri, Sayeh
Chihab, Hajar
Elhabazi, Abdellah
Wakrim, Lahcen
Benjelloun, Soumaya
author_sort Ezzikouri, Sayeh
collection PubMed
description BACKGROUND: The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Moroccan patients. METHODS: Using a TaqMan 5’ allelic discrimination assay, the Ser267Phe variant was genotyped in 286 chronic hepatitis B patients, 135 individuals with spontaneous clearance from HBV infection and 109 healthy controls negative for hepatitis B serological markers. RESULTS: In this cohort, we detected only wild-type genotype (S267S) in all groups. This polymorphism was not associated with the HBV infection status in Moroccan patients. CONCLUSIONS: The S267F variant is absent among Moroccans regardless of chronic HBV infection status.
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spelling pubmed-52702882017-02-01 Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status Ezzikouri, Sayeh Chihab, Hajar Elhabazi, Abdellah Wakrim, Lahcen Benjelloun, Soumaya BMC Infect Dis Research Article BACKGROUND: The sodium taurocholate co-transporting polypeptide, encoded by SLC10A1, was identified as a functional receptor for hepatitis B virus (HBV). The objective of this study was to determine if there was an association of the Ser267Phe variant (rs2296651) with HBV infection status in Moroccan patients. METHODS: Using a TaqMan 5’ allelic discrimination assay, the Ser267Phe variant was genotyped in 286 chronic hepatitis B patients, 135 individuals with spontaneous clearance from HBV infection and 109 healthy controls negative for hepatitis B serological markers. RESULTS: In this cohort, we detected only wild-type genotype (S267S) in all groups. This polymorphism was not associated with the HBV infection status in Moroccan patients. CONCLUSIONS: The S267F variant is absent among Moroccans regardless of chronic HBV infection status. BioMed Central 2017-01-26 /pmc/articles/PMC5270288/ /pubmed/28125961 http://dx.doi.org/10.1186/s12879-017-2214-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ezzikouri, Sayeh
Chihab, Hajar
Elhabazi, Abdellah
Wakrim, Lahcen
Benjelloun, Soumaya
Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title_full Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title_fullStr Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title_full_unstemmed Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title_short Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
title_sort lack of ser267phe variant of sodium taurocholate cotransporting polypeptide among moroccans regardless of hepatitis b virus infection status
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270288/
https://www.ncbi.nlm.nih.gov/pubmed/28125961
http://dx.doi.org/10.1186/s12879-017-2214-2
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