Cargando…

Metformin targets multiple signaling pathways in cancer

Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Yong, Yi, Yanhua, Liu, Yang, Liu, Xia, Keller, Evan T., Qian, Chao-Nan, Zhang, Jian, Lu, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270304/ https://www.ncbi.nlm.nih.gov/pubmed/28126011 http://dx.doi.org/10.1186/s40880-017-0184-9

Ejemplares similares

Wnt3a: functions and implications in cancer
por: He, Sha, et al.
Publicado: (2015)

Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer
por: Shen, Qian, et al.
Publicado: (2023)

Combined treatment with metformin and gefitinib overcomes primary resistance to EGFR-TKIs with EGFR mutation via targeting IGF-1R signaling pathway
por: Pan, Yong-hong, et al.
Publicado: (2018)

Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells
por: Olokpa, Emuejevoke, et al.
Publicado: (2022)

IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker
por: Chen, Qiuyan, et al.
Publicado: (2016)

Metformin inhibits esophageal squamous cell carcinoma-induced angiogenesis by suppressing JAK/STAT3 signaling pathway
por: Yang, Yi, et al.
Publicado: (2017)

Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways
por: Pan, Qi, et al.
Publicado: (2015)

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
por: Chowdhury, Anindya Roy, et al.
Publicado: (2020)

Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway
por: Zhu, Mengmeng, et al.
Publicado: (2016)

Influence of metformin on HIF-1 pathway in multiple myeloma
por: Kocemba-Pilarczyk, Kinga A., et al.
Publicado: (2020)

Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies
por: Ji, Ziyu, et al.
Publicado: (2023)

Low-dose metformin targets the lysosomal AMPK pathway through PEN2
por: Ma, Teng, et al.
Publicado: (2022)

Metformin: A New Inhibitor of the Wnt Signaling Pathway in Cancer
por: Conza, Domenico, et al.
Publicado: (2023)

Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells
por: XIE, YA, et al.
Publicado: (2014)

Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats
por: Liu, Yuansheng, et al.
Publicado: (2022)

Metformin limits osteoarthritis development and progression through activation of AMPK signalling
por: Li, Jun, et al.
Publicado: (2020)

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
por: Cheng, Demin, et al.
Publicado: (2021)

The Hippo signaling pathway: from multiple signals to the hallmarks of cancers: Hippo pathway: from multiple signals to the hallmarks of cancers
por: Zhu, Ning, et al.
Publicado: (2023)

Molecular mechanisms of ferroptosis and the potential therapeutic targets of ferroptosis signaling pathways for glioblastoma
por: Zhang, Meng, et al.
Publicado: (2022)

Metformin extends C. elegans lifespan through lysosomal pathway
por: Chen, Jie, et al.
Publicado: (2017)

Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway
por: Wang, Meng, et al.
Publicado: (2022)

Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome
por: Wang, Kexin, et al.
Publicado: (2023)

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer
por: FAN, CONG, et al.
Publicado: (2015)

Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer
por: Fan, Cong, et al.
Publicado: (2023)

Silencing RRM2 inhibits multiple myeloma by targeting the Wnt/β-catenin signaling pathway
por: Liu, Xia, et al.
Publicado: (2019)

Tumor microenvironment promotes prostate cancer cell dissemination via the Akt/mTOR pathway
por: Shi, Junlin, et al.
Publicado: (2018)

Metformin suppresses proliferation and invasion of drug‐resistant breast cancer cells by activation of the Hippo pathway
por: Liu, Jie, et al.
Publicado: (2020)

Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway
por: Li, Li, et al.
Publicado: (2015)

Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway
por: Ke, Jing, et al.
Publicado: (2017)

Metformin carbon nanodots promote odontoblastic differentiation of dental pulp stem cells by pathway of autophagy
por: Lu, Jinjin, et al.
Publicado: (2022)

Romidepsin targets multiple survival signaling pathways in malignant T cells
por: Valdez, B C, et al.
Publicado: (2015)

Metformin Inhibit Cervical Cancer Migration by Suppressing the FAK/Akt Signaling Pathway
por: Hakimee, Henna, et al.
Publicado: (2019)

Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling
por: Yang, Xu, et al.
Publicado: (2021)

The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic Target
por: Yang, Yun, et al.
Publicado: (2021)

Chemical Conversion of Human Fetal Astrocytes into Neurons through Modulation of Multiple Signaling Pathways
por: Yin, Jiu-Chao, et al.
Publicado: (2019)

Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
por: Tang, Jian-Cai, et al.
Publicado: (2017)

Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach
por: Nouri, Zeinab, et al.
Publicado: (2020)

Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer
por: Wen, Wei, et al.
Publicado: (2020)

Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling
por: Guo, Hongwei, et al.
Publicado: (2017)

Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
por: Sun, Jingchun, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_huf4r7fcv3hf5rlujtpcj9tvrg