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The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry

BACKGROUND: RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macrophages or indirectly through vascular normalization and increased T-lymphocyte inf...

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Detalles Bibliográficos
Autores principales:	Zhao, Hongjuan, Ning, Shoucheng, Nolley, Rosalie, Scicinski, Jan, Oronsky, Bryan, Knox, Susan J., Peehl, Donna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270305/ https://www.ncbi.nlm.nih.gov/pubmed/28149332 http://dx.doi.org/10.1186/s13148-017-0312-z

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