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Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?

Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa hav...

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Detalles Bibliográficos
Autores principales: Giacoppo, Sabrina, Mazzon, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/
https://www.ncbi.nlm.nih.gov/pubmed/28197175
http://dx.doi.org/10.4103/1673-5374.197125
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author Giacoppo, Sabrina
Mazzon, Emanuela
author_facet Giacoppo, Sabrina
Mazzon, Emanuela
author_sort Giacoppo, Sabrina
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.
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spelling pubmed-52704172017-02-14 Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis? Giacoppo, Sabrina Mazzon, Emanuela Neural Regen Res Invited Review Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids. Medknow Publications & Media Pvt Ltd 2016-12 /pmc/articles/PMC5270417/ /pubmed/28197175 http://dx.doi.org/10.4103/1673-5374.197125 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Giacoppo, Sabrina
Mazzon, Emanuela
Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title_full Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title_fullStr Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title_full_unstemmed Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title_short Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
title_sort can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/
https://www.ncbi.nlm.nih.gov/pubmed/28197175
http://dx.doi.org/10.4103/1673-5374.197125
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