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Subhypnotic doses of propofol impair spatial memory retrieval in rats

Abundant evidence indicates that propofol profoundly affects memory processes, although its specific effects on memory retrieval have not been clarified. A recent study has indicated that hippocampal glycogen synthase kinase-3β (GSK-3β) activity affects memory. Constitutively active GSK-3β is requir...

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Autores principales: Liu, Hu, Wang, Ting, Dai, Wei, Jiang, Zheng, Li, Yuan-hai, Liu, Xue-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270434/
https://www.ncbi.nlm.nih.gov/pubmed/28197192
http://dx.doi.org/10.4103/1673-5374.197137
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author Liu, Hu
Wang, Ting
Dai, Wei
Jiang, Zheng
Li, Yuan-hai
Liu, Xue-sheng
author_facet Liu, Hu
Wang, Ting
Dai, Wei
Jiang, Zheng
Li, Yuan-hai
Liu, Xue-sheng
author_sort Liu, Hu
collection PubMed
description Abundant evidence indicates that propofol profoundly affects memory processes, although its specific effects on memory retrieval have not been clarified. A recent study has indicated that hippocampal glycogen synthase kinase-3β (GSK-3β) activity affects memory. Constitutively active GSK-3β is required for memory retrieval, and propofol has been shown to inhibit GSK-3β. Thus, the present study examined whether propofol affects memory retrieval, and, if so, whether that effect is mediated through altered GSK-3β activity. Adult Sprague-Dawley rats were trained on a Morris water maze task (eight acquisition trials in one session) and subjected under the influence of a subhypnotic dose of propofol to a 24-hour probe trial memory retrieval test. The results showed that rats receiving pretest propofol (25 mg/kg) spent significantly less time in the target quadrant but showed no change in locomotor activity compared with those in the control group. Memory retrieval was accompanied by reduced phosphorylation of the serine-9 residue of GSK-3β in the hippocampus, whereas phosphorylation of the tyrosine-216 residue was unaffected. However, propofol blocked this retrieval-associated serine-9 phosphorylation. These findings suggest that subhypnotic propofol administration impairs memory retrieval and that the amnestic effects of propofol may be mediated by attenuated GSK-3β signaling in the hippocampus.
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spelling pubmed-52704342017-02-14 Subhypnotic doses of propofol impair spatial memory retrieval in rats Liu, Hu Wang, Ting Dai, Wei Jiang, Zheng Li, Yuan-hai Liu, Xue-sheng Neural Regen Res Research Article Abundant evidence indicates that propofol profoundly affects memory processes, although its specific effects on memory retrieval have not been clarified. A recent study has indicated that hippocampal glycogen synthase kinase-3β (GSK-3β) activity affects memory. Constitutively active GSK-3β is required for memory retrieval, and propofol has been shown to inhibit GSK-3β. Thus, the present study examined whether propofol affects memory retrieval, and, if so, whether that effect is mediated through altered GSK-3β activity. Adult Sprague-Dawley rats were trained on a Morris water maze task (eight acquisition trials in one session) and subjected under the influence of a subhypnotic dose of propofol to a 24-hour probe trial memory retrieval test. The results showed that rats receiving pretest propofol (25 mg/kg) spent significantly less time in the target quadrant but showed no change in locomotor activity compared with those in the control group. Memory retrieval was accompanied by reduced phosphorylation of the serine-9 residue of GSK-3β in the hippocampus, whereas phosphorylation of the tyrosine-216 residue was unaffected. However, propofol blocked this retrieval-associated serine-9 phosphorylation. These findings suggest that subhypnotic propofol administration impairs memory retrieval and that the amnestic effects of propofol may be mediated by attenuated GSK-3β signaling in the hippocampus. Medknow Publications & Media Pvt Ltd 2016-12 /pmc/articles/PMC5270434/ /pubmed/28197192 http://dx.doi.org/10.4103/1673-5374.197137 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Liu, Hu
Wang, Ting
Dai, Wei
Jiang, Zheng
Li, Yuan-hai
Liu, Xue-sheng
Subhypnotic doses of propofol impair spatial memory retrieval in rats
title Subhypnotic doses of propofol impair spatial memory retrieval in rats
title_full Subhypnotic doses of propofol impair spatial memory retrieval in rats
title_fullStr Subhypnotic doses of propofol impair spatial memory retrieval in rats
title_full_unstemmed Subhypnotic doses of propofol impair spatial memory retrieval in rats
title_short Subhypnotic doses of propofol impair spatial memory retrieval in rats
title_sort subhypnotic doses of propofol impair spatial memory retrieval in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270434/
https://www.ncbi.nlm.nih.gov/pubmed/28197192
http://dx.doi.org/10.4103/1673-5374.197137
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