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Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment

Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses. Genome-wide analyses have revealed that many ncRN...

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Detalles Bibliográficos
Autores principales: Takemata, Naomichi, Ohta, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270525/
https://www.ncbi.nlm.nih.gov/pubmed/27763805
http://dx.doi.org/10.1080/15476286.2016.1248020
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author Takemata, Naomichi
Ohta, Kunihiro
author_facet Takemata, Naomichi
Ohta, Kunihiro
author_sort Takemata, Naomichi
collection PubMed
description Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses. Genome-wide analyses have revealed that many ncRNAs are transcribed around regulatory DNA elements located proximal or distal to gene promoters, but their biological functions are largely unknown. Recently, it has been demonstrated in yeast and mouse that ncRNA transcription around gene promoters and enhancers facilitates DNA binding of transcription factors to their target sites. These results suggest universal roles of promoter/enhancer-associated ncRNAs in the recruitment of transcription factors to their binding sites.
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spelling pubmed-52705252017-02-22 Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment Takemata, Naomichi Ohta, Kunihiro RNA Biol Point of View Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses. Genome-wide analyses have revealed that many ncRNAs are transcribed around regulatory DNA elements located proximal or distal to gene promoters, but their biological functions are largely unknown. Recently, it has been demonstrated in yeast and mouse that ncRNA transcription around gene promoters and enhancers facilitates DNA binding of transcription factors to their target sites. These results suggest universal roles of promoter/enhancer-associated ncRNAs in the recruitment of transcription factors to their binding sites. Taylor & Francis 2016-10-20 /pmc/articles/PMC5270525/ /pubmed/27763805 http://dx.doi.org/10.1080/15476286.2016.1248020 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Point of View
Takemata, Naomichi
Ohta, Kunihiro
Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title_full Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title_fullStr Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title_full_unstemmed Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title_short Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment
title_sort role of non-coding rna transcription around gene regulatory elements in transcription factor recruitment
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270525/
https://www.ncbi.nlm.nih.gov/pubmed/27763805
http://dx.doi.org/10.1080/15476286.2016.1248020
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