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Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging
p53 transcriptional activity has been proposed to regulate both homeostasis and sarcopenia of skeletal muscle during aging. However, the exact molecular function of p53 remains to be clearly defined. We demonstrated a requirement of nuclear p53 S-nitrosylation in inducing a nitric oxide/PGC-1α-media...
Autores principales: | Baldelli, Sara, Ciriolo, Maria Rosa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270679/ https://www.ncbi.nlm.nih.gov/pubmed/28025407 http://dx.doi.org/10.18632/aging.101139 |
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