Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buff...

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Detalles Bibliográficos
Autores principales: Winerdal, Max, Urmaliya, Vijay, Winerdal, Malin E., Fredholm, Bertil B., Winqvist, Ola, Ådén, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271335/
https://www.ncbi.nlm.nih.gov/pubmed/28129361
http://dx.doi.org/10.1371/journal.pone.0170545
Descripción
Sumario:In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.

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