Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buff...

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Detalles Bibliográficos
Autores principales: Winerdal, Max, Urmaliya, Vijay, Winerdal, Malin E., Fredholm, Bertil B., Winqvist, Ola, Ådén, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271335/
https://www.ncbi.nlm.nih.gov/pubmed/28129361
http://dx.doi.org/10.1371/journal.pone.0170545
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author Winerdal, Max
Urmaliya, Vijay
Winerdal, Malin E.
Fredholm, Bertil B.
Winqvist, Ola
Ådén, Ulrika
author_facet Winerdal, Max
Urmaliya, Vijay
Winerdal, Malin E.
Fredholm, Bertil B.
Winqvist, Ola
Ådén, Ulrika
author_sort Winerdal, Max
collection PubMed
description In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.
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spelling pubmed-52713352017-02-06 Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia Winerdal, Max Urmaliya, Vijay Winerdal, Malin E. Fredholm, Bertil B. Winqvist, Ola Ådén, Ulrika PLoS One Research Article In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury. Public Library of Science 2017-01-27 /pmc/articles/PMC5271335/ /pubmed/28129361 http://dx.doi.org/10.1371/journal.pone.0170545 Text en © 2017 Winerdal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Winerdal, Max
Urmaliya, Vijay
Winerdal, Malin E.
Fredholm, Bertil B.
Winqvist, Ola
Ådén, Ulrika
Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title_full Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title_fullStr Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title_full_unstemmed Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title_short Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia
title_sort single dose caffeine protects the neonatal mouse brain against hypoxia ischemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271335/
https://www.ncbi.nlm.nih.gov/pubmed/28129361
http://dx.doi.org/10.1371/journal.pone.0170545
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