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Multidimensional nanomaterials for the control of stem cell fate
Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, surface chemistry, conductivity, and topographical microenvironment to regulate stem cell dif...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korea Nano Technology Research Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271342/ https://www.ncbi.nlm.nih.gov/pubmed/28191433 http://dx.doi.org/10.1186/s40580-016-0083-9 |
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author | Chueng, Sy-Tsong Dean Yang, Letao Zhang, Yixiao Lee, Ki-Bum |
author_facet | Chueng, Sy-Tsong Dean Yang, Letao Zhang, Yixiao Lee, Ki-Bum |
author_sort | Chueng, Sy-Tsong Dean |
collection | PubMed |
description | Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, surface chemistry, conductivity, and topographical microenvironment to regulate stem cell differentiation through multidimensional approaches to facilitate gene delivery, cell–cell, and cell–ECM interactions. In this review, nanomaterials are demonstrated to work both alone and synergistically to guide selective stem cell differentiation. From three different nanotechnology families, three approaches are shown: (1) soluble microenvironmental factors; (2) insoluble physical microenvironment; and (3) nano-topographical features. As regenerative medicine is heavily invested in effective stem cell therapy, this review is inspired to generate discussions in the potential clinical applications of multi-dimensional nanomaterials. |
format | Online Article Text |
id | pubmed-5271342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korea Nano Technology Research Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-52713422017-02-09 Multidimensional nanomaterials for the control of stem cell fate Chueng, Sy-Tsong Dean Yang, Letao Zhang, Yixiao Lee, Ki-Bum Nano Converg Review Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, surface chemistry, conductivity, and topographical microenvironment to regulate stem cell differentiation through multidimensional approaches to facilitate gene delivery, cell–cell, and cell–ECM interactions. In this review, nanomaterials are demonstrated to work both alone and synergistically to guide selective stem cell differentiation. From three different nanotechnology families, three approaches are shown: (1) soluble microenvironmental factors; (2) insoluble physical microenvironment; and (3) nano-topographical features. As regenerative medicine is heavily invested in effective stem cell therapy, this review is inspired to generate discussions in the potential clinical applications of multi-dimensional nanomaterials. Korea Nano Technology Research Society 2016-09-21 /pmc/articles/PMC5271342/ /pubmed/28191433 http://dx.doi.org/10.1186/s40580-016-0083-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Chueng, Sy-Tsong Dean Yang, Letao Zhang, Yixiao Lee, Ki-Bum Multidimensional nanomaterials for the control of stem cell fate |
title | Multidimensional nanomaterials for the control of stem cell fate |
title_full | Multidimensional nanomaterials for the control of stem cell fate |
title_fullStr | Multidimensional nanomaterials for the control of stem cell fate |
title_full_unstemmed | Multidimensional nanomaterials for the control of stem cell fate |
title_short | Multidimensional nanomaterials for the control of stem cell fate |
title_sort | multidimensional nanomaterials for the control of stem cell fate |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271342/ https://www.ncbi.nlm.nih.gov/pubmed/28191433 http://dx.doi.org/10.1186/s40580-016-0083-9 |
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