Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma

The antitumor response after therapeutic vaccination has a limited effect and seems to be related to the presence of T regulatory cells (Treg), which express the immunoregulatory molecules CTLA4 and Foxp3. The blockage of CTLA4 using antibodies has shown an effective antitumor response conducing to...

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Detalles Bibliográficos
Autores principales: Miguel, Antonio, Sendra, Luis, Noé, Verónica, Ciudad, Carles J, Dasí, Francisco, Hervas, David, Herrero, María José, Aliño, Salvador F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271385/
https://www.ncbi.nlm.nih.gov/pubmed/28176947
http://dx.doi.org/10.2147/OTT.S104393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271385/
https://www.ncbi.nlm.nih.gov/pubmed/28176947
http://dx.doi.org/10.2147/OTT.S104393

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