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Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma

The antitumor response after therapeutic vaccination has a limited effect and seems to be related to the presence of T regulatory cells (Treg), which express the immunoregulatory molecules CTLA4 and Foxp3. The blockage of CTLA4 using antibodies has shown an effective antitumor response conducing to...

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Detalles Bibliográficos
Autores principales:	Miguel, Antonio, Sendra, Luis, Noé, Verónica, Ciudad, Carles J, Dasí, Francisco, Hervas, David, Herrero, María José, Aliño, Salvador F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271385/ https://www.ncbi.nlm.nih.gov/pubmed/28176947 http://dx.doi.org/10.2147/OTT.S104393

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