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SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2’3’-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUM...

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Detalles Bibliográficos
Autores principales:	Cui, Ye, Yu, Huansha, Zheng, Xin, Peng, Rui, Wang, Qiang, Zhou, Yi, Wang, Rui, Wang, Jiehua, Qu, Bo, Shen, Nan, Guo, Qiang, Liu, Xing, Wang, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271409/ https://www.ncbi.nlm.nih.gov/pubmed/28095500 http://dx.doi.org/10.1371/journal.ppat.1006156

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