Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?

We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific surviva...

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Autores principales: Breyer, Johannes, Otto, Wolfgang, Burger, Maximilian, Hartmann, Arndt, Rubenwolf, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271480/
https://www.ncbi.nlm.nih.gov/pubmed/28149932
http://dx.doi.org/10.3233/BLC-160082
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author Breyer, Johannes
Otto, Wolfgang
Burger, Maximilian
Hartmann, Arndt
Rubenwolf, Peter C.
author_facet Breyer, Johannes
Otto, Wolfgang
Burger, Maximilian
Hartmann, Arndt
Rubenwolf, Peter C.
author_sort Breyer, Johannes
collection PubMed
description We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific survival, this report investigates the expression of AQP3 in associated CIS. Contrary to what we had expected, all CIS specimens were shown to exhibit strong AQP3 expression, suggesting loss of AQP3 in UBC is primarily associated with the ability of tumor cells for invasion but not with grading as sign of dedifferentiation.
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spelling pubmed-52714802017-01-30 Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading? Breyer, Johannes Otto, Wolfgang Burger, Maximilian Hartmann, Arndt Rubenwolf, Peter C. Bladder Cancer Short Communication We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. Whereas former studies demonstrated that loss of AQP3 was associated with invasive and high-grade disease and worse progression-free and cancer-specific survival, this report investigates the expression of AQP3 in associated CIS. Contrary to what we had expected, all CIS specimens were shown to exhibit strong AQP3 expression, suggesting loss of AQP3 in UBC is primarily associated with the ability of tumor cells for invasion but not with grading as sign of dedifferentiation. IOS Press 2017-01-27 /pmc/articles/PMC5271480/ /pubmed/28149932 http://dx.doi.org/10.3233/BLC-160082 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Breyer, Johannes
Otto, Wolfgang
Burger, Maximilian
Hartmann, Arndt
Rubenwolf, Peter C.
Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title_full Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title_fullStr Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title_full_unstemmed Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title_short Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?
title_sort aquaporin 3 expression loss in urothelial carcinoma: association with tumor invasion depth, but not with grading?
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271480/
https://www.ncbi.nlm.nih.gov/pubmed/28149932
http://dx.doi.org/10.3233/BLC-160082
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