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Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis

The major genetic risk factor for Alzheimer’s disease (AD), apolipoprotein E4 (ApoE4), has been suggested to have detrimental effects on neurons, including direct toxicity via apoptosis. Thioredoxin-1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the...

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Detalles Bibliográficos
Autores principales:	Persson, Torbjörn, Lattanzio, Francesca, Calvo-Garrido, Javier, Rimondini, Roberto, Rubio-Rodrigo, Marta, Sundström, Erik, Maioli, Silvia, Sandebring-Matton, Anna, Cedazo-Mínguez, Ángel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271484/ https://www.ncbi.nlm.nih.gov/pubmed/28035917 http://dx.doi.org/10.3233/JAD-150738

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