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Framing of grid cells within and beyond navigation boundaries

Grid cells represent an ideal candidate to investigate the allocentric determinants of the brain’s cognitive map. Most studies of grid cells emphasized the roles of geometric boundaries within the navigational range of the animal. Behaviors such as novel route-taking between local environments indic...

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Detalles Bibliográficos
Autores principales: Savelli, Francesco, Luck, JD, Knierim, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271608/
https://www.ncbi.nlm.nih.gov/pubmed/28084992
http://dx.doi.org/10.7554/eLife.21354
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author Savelli, Francesco
Luck, JD
Knierim, James J
author_facet Savelli, Francesco
Luck, JD
Knierim, James J
author_sort Savelli, Francesco
collection PubMed
description Grid cells represent an ideal candidate to investigate the allocentric determinants of the brain’s cognitive map. Most studies of grid cells emphasized the roles of geometric boundaries within the navigational range of the animal. Behaviors such as novel route-taking between local environments indicate the presence of additional inputs from remote cues beyond the navigational borders. To investigate these influences, we recorded grid cells as rats explored an open-field platform in a room with salient, remote cues. The platform was rotated or translated relative to the room frame of reference. Although the local, geometric frame of reference often exerted the strongest control over the grids, the remote cues demonstrated a consistent, sometimes dominant, countervailing influence. Thus, grid cells are controlled by both local geometric boundaries and remote spatial cues, consistent with prior studies of hippocampal place cells and providing a rich representational repertoire to support complex navigational (and perhaps mnemonic) processes. DOI: http://dx.doi.org/10.7554/eLife.21354.001
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spelling pubmed-52716082017-01-30 Framing of grid cells within and beyond navigation boundaries Savelli, Francesco Luck, JD Knierim, James J eLife Neuroscience Grid cells represent an ideal candidate to investigate the allocentric determinants of the brain’s cognitive map. Most studies of grid cells emphasized the roles of geometric boundaries within the navigational range of the animal. Behaviors such as novel route-taking between local environments indicate the presence of additional inputs from remote cues beyond the navigational borders. To investigate these influences, we recorded grid cells as rats explored an open-field platform in a room with salient, remote cues. The platform was rotated or translated relative to the room frame of reference. Although the local, geometric frame of reference often exerted the strongest control over the grids, the remote cues demonstrated a consistent, sometimes dominant, countervailing influence. Thus, grid cells are controlled by both local geometric boundaries and remote spatial cues, consistent with prior studies of hippocampal place cells and providing a rich representational repertoire to support complex navigational (and perhaps mnemonic) processes. DOI: http://dx.doi.org/10.7554/eLife.21354.001 eLife Sciences Publications, Ltd 2017-01-13 /pmc/articles/PMC5271608/ /pubmed/28084992 http://dx.doi.org/10.7554/eLife.21354 Text en © 2017, Savelli et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Savelli, Francesco
Luck, JD
Knierim, James J
Framing of grid cells within and beyond navigation boundaries
title Framing of grid cells within and beyond navigation boundaries
title_full Framing of grid cells within and beyond navigation boundaries
title_fullStr Framing of grid cells within and beyond navigation boundaries
title_full_unstemmed Framing of grid cells within and beyond navigation boundaries
title_short Framing of grid cells within and beyond navigation boundaries
title_sort framing of grid cells within and beyond navigation boundaries
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271608/
https://www.ncbi.nlm.nih.gov/pubmed/28084992
http://dx.doi.org/10.7554/eLife.21354
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