Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endo...

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Detalles Bibliográficos
Autores principales: van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Oude Elferink, Ronald P. J., Paulusma, Coen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272906/
https://www.ncbi.nlm.nih.gov/pubmed/27628304
http://dx.doi.org/10.1007/s00018-016-2360-5

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