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New strategies for cancer immunotherapy: targeting regulatory T cells
The immunosuppressive action of regulatory T (T(reg)) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating T(reg) cells and expression of specific molecules, sugg...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273791/ https://www.ncbi.nlm.nih.gov/pubmed/28129791 http://dx.doi.org/10.1186/s13073-017-0402-8 |
| Sumario: | The immunosuppressive action of regulatory T (T(reg)) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating T(reg) cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy. |
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