Cargando…
Contribution of Neuroepigenetics to Huntington’s Disease
Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington’s disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276857/ https://www.ncbi.nlm.nih.gov/pubmed/28194101 http://dx.doi.org/10.3389/fnhum.2017.00017 |
_version_ | 1782502354468208640 |
---|---|
author | Francelle, Laetitia Lotz, Caroline Outeiro, Tiago Brouillet, Emmanuel Merienne, Karine |
author_facet | Francelle, Laetitia Lotz, Caroline Outeiro, Tiago Brouillet, Emmanuel Merienne, Karine |
author_sort | Francelle, Laetitia |
collection | PubMed |
description | Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington’s disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of epigenetic changes in HD, in the light of recent advances in neuroepigenetics. We particularly discuss studies using genome-wide scale approaches that provide insights into the relationship between epigenetic regulations, gene expression and neuronal activity in normal and diseased neurons, including HD neurons. We propose that cell-type specific techniques and 3D-based methods will advance knowledge of epigenome in the context of brain region vulnerability in neurodegenerative diseases. A better understanding of the mechanisms underlying epigenetic changes and of their consequences in neurodegenerative diseases is required to design therapeutic strategies more effective than current strategies based on histone deacetylase (HDAC) inhibitors. Researches in HD may play a driving role in this process. |
format | Online Article Text |
id | pubmed-5276857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52768572017-02-13 Contribution of Neuroepigenetics to Huntington’s Disease Francelle, Laetitia Lotz, Caroline Outeiro, Tiago Brouillet, Emmanuel Merienne, Karine Front Hum Neurosci Neuroscience Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington’s disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of epigenetic changes in HD, in the light of recent advances in neuroepigenetics. We particularly discuss studies using genome-wide scale approaches that provide insights into the relationship between epigenetic regulations, gene expression and neuronal activity in normal and diseased neurons, including HD neurons. We propose that cell-type specific techniques and 3D-based methods will advance knowledge of epigenome in the context of brain region vulnerability in neurodegenerative diseases. A better understanding of the mechanisms underlying epigenetic changes and of their consequences in neurodegenerative diseases is required to design therapeutic strategies more effective than current strategies based on histone deacetylase (HDAC) inhibitors. Researches in HD may play a driving role in this process. Frontiers Media S.A. 2017-01-30 /pmc/articles/PMC5276857/ /pubmed/28194101 http://dx.doi.org/10.3389/fnhum.2017.00017 Text en Copyright © 2017 Francelle, Lotz, Outeiro, Brouillet and Merienne. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Francelle, Laetitia Lotz, Caroline Outeiro, Tiago Brouillet, Emmanuel Merienne, Karine Contribution of Neuroepigenetics to Huntington’s Disease |
title | Contribution of Neuroepigenetics to Huntington’s Disease |
title_full | Contribution of Neuroepigenetics to Huntington’s Disease |
title_fullStr | Contribution of Neuroepigenetics to Huntington’s Disease |
title_full_unstemmed | Contribution of Neuroepigenetics to Huntington’s Disease |
title_short | Contribution of Neuroepigenetics to Huntington’s Disease |
title_sort | contribution of neuroepigenetics to huntington’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276857/ https://www.ncbi.nlm.nih.gov/pubmed/28194101 http://dx.doi.org/10.3389/fnhum.2017.00017 |
work_keys_str_mv | AT francellelaetitia contributionofneuroepigeneticstohuntingtonsdisease AT lotzcaroline contributionofneuroepigeneticstohuntingtonsdisease AT outeirotiago contributionofneuroepigeneticstohuntingtonsdisease AT brouilletemmanuel contributionofneuroepigeneticstohuntingtonsdisease AT meriennekarine contributionofneuroepigeneticstohuntingtonsdisease |