Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression

The physical properties of the extracellular matrix (ECM), such as stiffness, are involved in the determination of the characteristics of cancer cells, including chemotherapy sensitivity. Resistance to chemotherapy is often linked to dysfunction of tumor suppressor p53; however, it remains elusive w...

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Detalles Bibliográficos
Autores principales: Ebata, Takahiro, Mitsui, Yasumasa, Sugimoto, Wataru, Maeda, Miho, Araki, Keigo, Machiyama, Hiroaki, Harada, Ichiro, Sawada, Yasuhiro, Fujita, Hideaki, Hirata, Hiroaki, Kawauchi, Keiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278210/
https://www.ncbi.nlm.nih.gov/pubmed/28191463
http://dx.doi.org/10.1155/2017/5158961

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