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Deceiving proteins! A case of lymphoma and high creatinine

Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins....

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Autores principales: Metraiah, El Hakem Abdelkarim, Regan, Helen, Louw, Johanna, Kidder, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278318/
https://www.ncbi.nlm.nih.gov/pubmed/28115403
http://dx.doi.org/10.1136/bcr-2016-217946
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author Metraiah, El Hakem Abdelkarim
Regan, Helen
Louw, Johanna
Kidder, Dana
author_facet Metraiah, El Hakem Abdelkarim
Regan, Helen
Louw, Johanna
Kidder, Dana
author_sort Metraiah, El Hakem Abdelkarim
collection PubMed
description Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine.
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spelling pubmed-52783182017-02-07 Deceiving proteins! A case of lymphoma and high creatinine Metraiah, El Hakem Abdelkarim Regan, Helen Louw, Johanna Kidder, Dana BMJ Case Rep Article Estimation of kidney function by measuring serum creatinine is one the commonest laboratory tests conducted in clinical practice. Enzymatic methods are often used to measure serum creatinine. Clinicians should be aware of the limitations of these methods, such as test interference with paraproteins.We present a case of falsely elevated serum creatinine in a patient referred for renal biopsy. The combination of fluctuating creatinine and normal blood urea level was unusual. Serum protein electrophoresis revealed the presence of an IgM paraprotein. Further investigations confirmed an underlying diagnosis of lymphoplasmacytoid lymphoma. This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine. BMJ Publishing Group 2017-01-23 /pmc/articles/PMC5278318/ /pubmed/28115403 http://dx.doi.org/10.1136/bcr-2016-217946 Text en 2017 BMJ Publishing Group Ltd This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Article
Metraiah, El Hakem Abdelkarim
Regan, Helen
Louw, Johanna
Kidder, Dana
Deceiving proteins! A case of lymphoma and high creatinine
title Deceiving proteins! A case of lymphoma and high creatinine
title_full Deceiving proteins! A case of lymphoma and high creatinine
title_fullStr Deceiving proteins! A case of lymphoma and high creatinine
title_full_unstemmed Deceiving proteins! A case of lymphoma and high creatinine
title_short Deceiving proteins! A case of lymphoma and high creatinine
title_sort deceiving proteins! a case of lymphoma and high creatinine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278318/
https://www.ncbi.nlm.nih.gov/pubmed/28115403
http://dx.doi.org/10.1136/bcr-2016-217946
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