Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Fingolimod, also known as FTY720, is an analogue of the sphingolipid sphingosine, which has been proved to be neuroprotective in rodent models of Alzheimer’s disease (AD). Several cellular and molecular targets underlying the neuroprotective effects of FTY720 have been recently identified. However,...

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Detalles Bibliográficos
Autores principales: Joshi, Pooja, Gabrielli, Martina, Ponzoni, Luisa, Pelucchi, Silvia, Stravalaci, Matteo, Beeg, Marten, Mazzitelli, Sonia, Braida, Daniela, Sala, Mariaelvina, Boda, Enrica, Buffo, Annalisa, Gobbi, Marco, Gardoni, Fabrizio, Matteoli, Michela, Marcello, Elena, Verderio, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278353/
https://www.ncbi.nlm.nih.gov/pubmed/28134307
http://dx.doi.org/10.1038/srep41734

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