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Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D
We describe and share a device, methodology and image analysis algorithms, which allow up to 66 spheroids to be arranged into a gel-based array directly from a culture plate for downstream processing and analysis. Compared to processing individual samples, the technique uses 11-fold less reagents, s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278392/ https://www.ncbi.nlm.nih.gov/pubmed/28134245 http://dx.doi.org/10.1038/srep41160 |